Tesamorelin Peptide | 20mg | 3ml
Tesamorelin is a synthetic peptide analogue of human growth hormone–releasing hormone (GHRH 1–44), engineered for research use in studying hypothalamic–pituitary communication and growth hormone regulatory pathways. Structural modifications increase its stability compared with native GHRH, allowing it to function reliably in controlled laboratory environments. In biochemical and cellular research systems, Tesamorelin binds to and activates the GHRH receptor found on pituitary‑derived cells, initiating intracellular signalling cascades that regulate growth hormone synthesis and secretion. Experimental work commonly evaluates receptor‑binding characteristics, cAMP‑dependent signalling activity, and downstream transcriptional responses under defined exposure conditions. The molecular effects observed vary with concentration, exposure duration, and model system, and are used to characterise GHRH receptor signalling rather than to infer physiological outcomes.
Strength
20mg
Concentration
6.67 mg/ml
Purity
≥99% HPLC
COA
Included
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- Same-day UK dispatch on orders placed before 3pm GMT.
- Free UK shipping over £100, tracked and next working day.
- Cold-chain packed: sealed foil pouch, ice packs, plain outer box.
- Batch-specific Certificate of Analysis included.
| Designation | GHRH(1-44) analogue |
| CAS Number | 218949-48-5 |
| Molecular Formula | C₂₂₁H₃₆₆N₇₂O₆₇S |
| Molecular Weight | 5135.9 g/mol |
| Strength | 20mg |
| Concentration | 6.67 mg/ml |
| Presentation | 3ml Vial |
| Purity | ≥99% (HPLC) |
| Storage | Must be kept in a refrigerator at 2°C–8°C for optimal potency. |
| Certificate of Analysis | Batch-specific COA included |
How we ship it
Every pre-mixed vial leaves the UK cold and arrives in a plain box. Refrigerate on arrival at 2–8 °C.
Chilled
Vials travel with frozen gel packs inside a sealed foil pouch, which holds temperature for roughly seven days in transit.
Insulated
The pouch sits inside a wool-lined envelope, so the cold chain survives a normal courier journey.
Discreet
Plain outer box with no branding and nothing on the label that names the contents.
Same-day dispatch
Order before 3pm GMT, Monday to Friday.
Free over £100
Tracked UK delivery, next working day.
2–8 °C on arrival
Refrigerate as soon as the parcel lands.
TESAMORELIN
£125.00 · Qty 1
Tesamorelin peptide: chemistry, format and quality
Tesamorelin is a synthetic analogue of human growth-hormone-releasing hormone — the full 44-residue GHRH (1–44) sequence with a modification at the N-terminus that protects it from the enzymatic cleavage that clears native GHRH within minutes. That stability is why it is a dependable tool for studying GHRH-receptor signalling in the laboratory. Ours is supplied pre-mixed as a solution in a sealed 3 ml vial, 20mg per vial, HPLC-verified with a batch Certificate of Analysis, synthesised and dispatched from our UK facility.
Research use only. Tesamorelin is supplied strictly for in-vitro laboratory research. This page describes chemistry, format, quality and handling. It does not describe dosing, administration or use in humans or animals, and makes no therapeutic claims.
Tesamorelin at a glance
| Compound | Tesamorelin, synthetic GHRH (1–44) analogue |
| Strength | 20mg in a 3 ml sealed vial |
| Format | Pre-mixed solution — no powder, no reconstitution step |
| Reference values | C₂₂₁H₃₆₆N₇₂O₆₇S · 5135.9 g/mol · CAS 218949-48-5 |
| Purity | ≥99% by HPLC, verified per batch |
| Certificate of Analysis | Batch-specific COA with every order; samples in the COA library |
| Storage | 2–8 °C, sealed, protected from light; do not freeze |
| Origin | Synthesised and dispatched from our UK facility |
What tesamorelin is, chemically
Native GHRH is a 44-amino-acid peptide released by the hypothalamus; its first two residues are the site attacked by dipeptidyl peptidase-4, which is why the natural hormone has a half-life of minutes. Tesamorelin keeps the full 1–44 sequence and adds a trans-3-hexenoyl group to the N-terminal tyrosine, blocking that cleavage without changing the receptor-binding region. It is therefore the closest of the common GHRH analogues to the native hormone: the whole sequence, stabilised, rather than a truncated or substituted fragment.
Tesamorelin vs CJC-1295, sermorelin and ipamorelin
Four compounds are routinely confused in growth-hormone research, and they are not interchangeable.
| What it is | Receptor | |
|---|---|---|
| Tesamorelin | Full GHRH (1–44), N-terminally stabilised | GHRH receptor |
| Sermorelin | GHRH (1–29), the shortest fully active fragment, unmodified | GHRH receptor |
| CJC-1295 (No DAC) | GHRH (1–29) with four amino-acid substitutions for stability (Mod GRF 1-29) | GHRH receptor |
| Ipamorelin | A pentapeptide growth-hormone secretagogue — a different peptide family | Ghrelin / GHS receptor (GHSR-1a) |
The first three act at the same receptor and differ in length and in how they achieve stability; ipamorelin acts at a different receptor entirely, which is why it is studied alongside a GHRH analogue rather than instead of one — our Hulk Stack pairs CJC-1295 with DAC and ipamorelin for exactly that reason. Tesamorelin is the choice when a study needs the full-length sequence.
How tesamorelin is studied
In biochemical and cellular systems tesamorelin binds and activates the GHRH receptor on pituitary-derived cells, and the work that follows characterises receptor-binding behaviour, cAMP-dependent signalling and the downstream transcriptional responses tied to growth-hormone synthesis and secretion. It is used as a molecular tool for GHRH-receptor activation studies, in pituitary-based models of growth-hormone regulation, in stability and receptor-selectivity comparisons against other analogues, and as a reference compound in neuroendocrine research. These are laboratory observations that vary with concentration, exposure and model, and are not established effects in humans or animals. The tesamorelin guide has more on the literature.
Regulatory position
Tesamorelin is approved as a prescription medicine in the United States, under a brand name, for one specific indication. It is not a licensed medicine in the UK, and nothing on this page relates to that use: the material supplied here is a research-grade reference compound for in-vitro work, labelled accordingly.
Pre-mixed tesamorelin vs lyophilised
Most UK suppliers ship tesamorelin as a lyophilised powder to reconstitute. Ours is supplied already in solution, so there is no reconstitution step and the concentration in the key facts above holds for every vial in the batch. A solution has to stay cold: every vial ships chilled in an insulated pouch, is refrigerated at 2–8 °C on arrival, and should be used within the storage window on the label. Larger peptides are generally more prone to aggregation on freeze–thaw than short ones, so do not freeze it.
Quality: HPLC purity and the Certificate of Analysis
Every batch is verified by HPLC at 99%+ purity, the certificate records the value measured for that batch, and a batch-specific COA ships with every order. Sample certificates are viewable in the COA library before you buy.
Storage and handling
- Refrigerate at 2–8 °C on arrival; keep the vial sealed and protected from light; do not freeze.
- Draw from the vial with standard aseptic laboratory technique.
- Check the certificate for the recorded appearance and the storage window for that lot.
Buying tesamorelin in the UK: what to check
- One stated strength everywhere — a listing that quotes one figure in its title and another on the certificate is a sign the copy is not maintained. Ours is 20mg per vial, on the label and the certificate.
- A batch-specific Certificate of Analysis naming the batch and method, viewable before you order.
- Format. Powder needs reconstitution; a pre-mixed solution needs cold-chain delivery and a refrigerator.
- Which analogue you actually need — full-length (tesamorelin), 1–29 (sermorelin, CJC-1295) or a secretagogue (ipamorelin); see the table above.
- Legal status. Tesamorelin is lawful to buy and possess in the UK for laboratory research. It is not a UK-licensed medicine, and every vial is supplied and labelled for in-vitro research use only.
Tesamorelin: research FAQs
- What is Tesamorelin?
- Tesamorelin is a synthetic peptide analogue of human growth hormone-releasing hormone (GHRH 1-44), belonging to the GHRH family of neuroendocrine peptides. Structural modifications to the native sequence increase its stability, allowing it to function reliably in controlled laboratory conditions. It is supplied strictly as a research chemical for in-vitro laboratory research use only.
- What is Tesamorelin studied for in research?
- In biochemical and cellular research systems, Tesamorelin has been investigated in preclinical and in-vitro work for its binding to and activation of the GHRH receptor expressed on pituitary-derived cells, and the intracellular signalling cascades associated with growth hormone synthesis and secretion that follow. Such studies commonly characterise receptor-binding behaviour, cAMP-dependent signalling activity, and downstream transcriptional responses under defined exposure conditions. These are laboratory observations that vary with concentration, exposure duration, and model system, and are used to characterise GHRH receptor signalling rather than to infer physiological outcomes in humans or animals.
- Is Tesamorelin legal to buy in the UK?
- Tesamorelin is legal to buy and possess in the UK for laboratory research purposes. It is not a licensed medicine and cannot be sold for human or veterinary use or consumption. Every vial ships labelled for in-vitro research use only.
- What purity is your Tesamorelin, and is it lab-tested?
- Our Tesamorelin is verified to 99%+ purity by HPLC analysis. The figure printed on each batch's Certificate of Analysis is the actual lab-recorded value for that batch, not a marketing claim. Material is synthesised and dispatched from our own UK facility rather than imported or repackaged, and is supplied for in-vitro research use only.
- Does Tesamorelin come with a Certificate of Analysis?
- Yes. A batch-specific Certificate of Analysis (COA) ships with every order, documenting the purity and identity results for the material you receive. You can also view sample COAs in our COA library before purchasing. All material is supplied for in-vitro research use only.
- How is Tesamorelin supplied, stored and handled for research?
- Tesamorelin is supplied in a sealed vial and shipped cold-chain. Refrigerate at 2°C–8°C as indicated on the label, keep the vial sealed and away from light, and check the batch Certificate of Analysis supplied with your order for the recorded appearance and presentation. Handling should follow standard aseptic laboratory practice, and the material is intended solely for in-vitro research use.
- Is your Tesamorelin pre-mixed or a powder?
- Pre-mixed. Ours is supplied already in solution in a sealed 3 ml vial, so there is no reconstitution step and no bacteriostatic water to buy. It ships cold-chain, is refrigerated at 2°C–8°C on arrival, must not be frozen, and should be used within the storage window on the label.
- How does Tesamorelin differ from CJC-1295, Sermorelin and Ipamorelin?
- Tesamorelin is the full GHRH (1–44) sequence with an N-terminal modification that blocks enzymatic cleavage. Sermorelin is the unmodified 1–29 fragment, and CJC-1295 (No DAC) is the 1–29 fragment with four substitutions for stability; all three act at the GHRH receptor. Ipamorelin is a different peptide family altogether — a growth-hormone secretagogue acting at the ghrelin receptor (GHSR-1a) — which is why it is studied alongside a GHRH analogue rather than instead of one.
- Is Tesamorelin a licensed medicine in the UK?
- No. Tesamorelin is approved as a prescription medicine in the United States for one specific indication, but it is not a licensed medicine in the UK. The material supplied here is research-grade, ships labelled for in-vitro research use only, and nothing on this site relates to any medical use.
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