PT-141 (Bremelanotide) | 20mg | 3ml
Strength
20mg
Purity
≥99% HPLC
COA
Included
PT‑141 (also known as bremelanotide) is a synthetic cyclic heptapeptide melanocortin‑receptor agonist derived structurally from Melanotan II. It is produced by modifying the C‑terminus of the MT‑II scaffold — replacing the terminal amide with a hydroxyl group — yielding a related cyclic peptide with a distinct receptor‑selectivity profile while retaining the lactam‑bridged, enzymatically stable architecture of its parent compound. These properties make PT‑141 a well‑defined reference peptide for studying melanocortin signalling under controlled laboratory conditions.\n\nIn biochemical and cellular research systems, PT‑141 acts as an agonist at the centrally expressed melanocortin receptors MC3R and MC4R, with comparatively higher potency at MC4R and substantially reduced activity at MC1R relative to Melanotan II. This shift toward MC4R selectivity makes PT‑141 a useful tool for isolating MC4R‑mediated signalling — including G‑protein‑coupled cAMP and phospholipase‑C cascades, intracellular calcium flux, and ERK/MAPK pathway activation — within neuronal and receptor‑expressing model systems. The molecular responses observed vary with receptor subtype, concentration, exposure time, and experimental model, and PT‑141 is used to characterise melanocortin‑receptor signalling rather than to infer defined biological or physiological outcomes.
Free Metal pen — worth £25
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COA: PT-141_COA_mypeptides.pdf
| Designation | Cyclic melanocortin heptapeptide (bremelanotide) |
| CAS Number | 189691-06-3 |
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular Weight | 1025.2 g/mol |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Strength | 20mg |
| Presentation | 3ml Vial , Pen and Needles |
| Purity | ≥99% (HPLC) |
| Storage | Must be kept in a refrigerator at 2°C–8°C for optimal potency. |
| Certificate of Analysis | Batch-specific COA included |
PT-141
£100.00
PT-141 — research FAQs
- What is PT-141?
- PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide melanocortin-receptor agonist derived structurally from Melanotan II. Replacing the C-terminal amide of the MT-II scaffold with a hydroxyl group yields a related cyclic peptide with a distinct receptor-selectivity profile, while retaining the lactam-bridged, enzymatically stable architecture. It is supplied strictly for in-vitro laboratory research use only.
- What is PT-141 studied for in research?
- In biochemical and cellular systems PT-141 acts as an agonist at the centrally expressed melanocortin receptors MC3R and MC4R, with comparatively higher potency at MC4R and substantially reduced activity at MC1R relative to Melanotan II. That selectivity makes it useful for isolating MC4R-mediated signalling — G-protein-coupled cAMP and phospholipase-C cascades, intracellular calcium flux and ERK/MAPK activation — in neuronal and receptor-expressing models. These are laboratory observations only; responses vary with receptor subtype, concentration, exposure time and model.
- How does PT-141 differ from Melanotan II?
- They share the same cyclic scaffold and differ at the C-terminus: Melanotan II is amidated (-NH₂) while PT-141 carries a free acid (-OH). That single change shifts PT-141 toward MC4R selectivity, whereas Melanotan II is a broad, non-selective agonist across MC1R, MC3R, MC4R and MC5R. Researchers often use the pair comparatively in selectivity studies.
- Is PT-141 legal to buy in the UK?
- PT-141 is legal to buy and possess in the UK for laboratory research purposes. It is not a licensed medicine in the UK and cannot be sold for human or veterinary consumption. Note that bremelanotide is approved as a prescription medicine in some other jurisdictions; material supplied here is research-grade and ships labelled for in-vitro research use only.
- What purity is your PT-141, and is it lab-tested?
- Our PT-141 is verified at 99%+ purity by HPLC analysis. The figure printed on each batch's Certificate of Analysis is the actual value recorded in the laboratory, not a marketing claim.
- How is PT-141 supplied, stored and handled for research?
- PT-141 is supplied in a sealed vial and shipped cold-chain. Refrigerate at 2°C–8°C as indicated on the label, keep the vial sealed and away from light, and check the batch Certificate of Analysis supplied with your order for the recorded appearance and presentation. Handling should follow standard aseptic laboratory practice.