CJC-1295 (No DAC) | 3mg | 3ml

CJC-1295 — written CJC 1295 or CJC1295 about as often as with the hyphen — is a synthetic analogue of growth-hormone-releasing hormone built on the GHRH (1–29) sequence. The variant supplied here is the No-DAC form, which the literature more precisely calls Mod GRF (1-29): the modified 29-residue chain without the drug-affinity complex that the conjugated version carries. Ours is supplied pre-mixed as a solution in a sealed 3 ml vial, 3mg per vial, HPLC-verified with a batch Certificate of Analysis, synthesised and dispatched from our UK facility.

Research use only. CJC-1295 is supplied strictly for in-vitro laboratory research. This page describes chemistry, format, quality and handling. It does not describe dosing, administration or use in humans or animals, and makes no therapeutic claims.

CJC-1295 (No DAC) at a glance

What "No DAC" actually means

Two different molecules are sold under the name CJC-1295, and the difference is the first thing to establish when comparing suppliers.

• CJC-1295 with DAC carries a drug-affinity complex — a maleimidopropionyl group appended to the chain that lets the peptide bind covalently to serum albumin. That conjugation is the entire point of the DAC version, and it is heavy: the with-DAC molecule is C₁₆₅H₂₆₉N₄₇O₄₆ at roughly 3,647 g/mol.
• CJC-1295 No DAC is the unconjugated chain — C₁₅₂H₂₅₂N₄₄O₄₂, 3,367.9 g/mol. With no albumin-binding group attached it behaves as a short-lived GHRH analogue, which is why most of the literature calls it Mod GRF (1-29) rather than CJC-1295 at all.

The mass on the certificate settles it, and the gap between the two is about 279 g/mol — far too large to be a rounding difference. Our batch certificate names the product "CJC-1295 (No DAC)" and reports the unconjugated formula and mass above. A certificate reporting ~3,647 g/mol describes the conjugate; a listing with no certificate describes nothing at all.

CJC-1295 and Ipamorelin: that is the other product

Search results for "CJC-1295 Ipamorelin" point at a pairing, not at this single vial, and the two should not be confused. Our Hulk Stack supplies CJC-1295 with DAC together with Ipamorelin, pre-mixed in one vial — a GHRH analogue alongside a selective growth-hormone secretagogue, which is the combination that phrase usually refers to. It is deliberately kept as a separate listing with "with DAC" in its title so the variant is never in doubt. The vial on this page is the No-DAC single, which is what you want for work on the unconjugated analogue on its own, or as the control arm against the conjugate.

The GHRH analogue family: which name is which

The family is easy to mix up because three of the four are built on the same 29-residue fragment. The modifications are what distinguish them: substitutions that resist enzymatic cleavage in the CJC/Mod GRF variants, none in sermorelin, and a different parent sequence entirely in tesamorelin.

How CJC-1295 (No DAC) is studied

Published in-vitro and preclinical work uses this compound as a GHRH-receptor tool: binding to and activation of the GHRH receptor on pituitary-derived cell lines, the G-protein-coupled cAMP cascade that follows, and the downstream signalling and transcriptional responses measured under short-duration exposure. Because the unconjugated form is not albumin-bound, it is also used as the short-acting comparator in structure–activity work on GHRH analogues, where the point of the experiment is precisely to isolate what the drug-affinity complex changes. Responses reported in these systems vary with concentration, exposure time, cell model and study design; they are laboratory observations and not established effects in humans or animals. The CJC-1295 guide goes further into the literature.

Pre-mixed CJC-1295 vs lyophilised

Almost every UK listing for CJC-1295 is a lyophilised powder that has to be reconstituted with bacteriostatic water before use. Ours is supplied already in solution: no reconstitution step, no bacteriostatic water to buy separately, no pipetting error introduced at the bench, and the concentration shown in the key facts above holds for every vial in the batch. The trade-off is cold chain — a solution ships chilled in an insulated pouch, goes into a 2–8 °C refrigerator on arrival, and should be used within the storage window on the label rather than kept as shelf stock.

Quality: HPLC purity and the Certificate of Analysis

CJC-1295 is one of the products whose chemistry on this page comes directly from the laboratory certificate rather than from reference tables. Every batch is verified by reversed-phase HPLC at 99%+ purity, and the certificate records the measured value, the appearance and the batch identifier for that specific lot. A batch-specific COA ships with every order, and sample certificates — including this compound's — are viewable in the COA library before you buy.

Storage and handling

• Refrigerate at 2–8 °C on arrival; keep the vial sealed and protected from light.
• Do not freeze. Freeze–thaw cycling damages peptides already in solution.
• Draw from the vial with standard aseptic laboratory technique.
• Check the certificate for the recorded appearance and the storage window for that lot.

Buying CJC-1295 in the UK: what to check

1. DAC or No DAC. The two are different reagents sold under one name; the formula and mass on the certificate tell you which is in the vial.
2. Mass per vial and, for a solution, the concentration — the two figures most listings blur together.
3. A batch-specific Certificate of Analysis naming the batch, the method and the appearance, viewable before you order.
4. Format. Powder needs bacteriostatic water and a reconstitution step; a pre-mixed solution needs cold-chain delivery and a refrigerator.
5. Legal status. CJC-1295 is lawful to buy and possess in the UK for laboratory research. It is not a licensed medicine, and every vial is supplied and labelled for in-vitro research use only.