What is the Hulk Stack?
6 min read · Updated July 2026 · MY PEPTIDES Research Team
Key facts
The Hulk Stack is a dual-peptide research set pairing CJC-1295 with DAC and Ipamorelin at 20mg total. Both compounds act within the growth-hormone (somatotropic) axis, but through different receptors, which is the reason they are studied together: CJC-1295 is a growth-hormone-releasing hormone (GHRH) analogue that activates the GHRH receptor on pituitary somatotrophs, while Ipamorelin is a selective agonist at the ghrelin / growth-hormone secretagogue receptor (GHSR-1a) on the same cells. Examining both within one experimental system lets researchers compare convergent versus independent signalling, receptor cross-talk, and dual-pathway regulatory responses under defined conditions. Importantly, this set uses CJC-1295 WITH DAC — a different variant from the No-DAC form (also called Mod GRF 1-29) sold as a single compound. DAC is a drug-affinity complex that binds serum albumin, markedly extending the circulating half-life relative to the unconjugated peptide, so the two variants show substantially different pharmacokinetic behaviour in experimental models and are not interchangeable in a study design. Observed responses vary with concentration, exposure time and model system. Supplied strictly for in-vitro laboratory research use only — not for human or veterinary use, and carrying no therapeutic claims.
The Hulk Stack is a dual-peptide research set pairing CJC-1295 with DAC and Ipamorelin, at 20mg total. It is the growth-hormone-axis counterpart to our tissue-repair sets: two compounds that act on the same pituitary cells through different receptors.
Research use only. This set is supplied strictly for in-vitro laboratory research. This page does not describe dosing, administration, or use in humans or animals, and makes no therapeutic claims.
The DAC distinction — read this first
This is the single most important thing to get right about the Hulk Stack, because it is the most common point of confusion in the literature and in supplier catalogues.
CJC-1295 exists in two forms, and they are not interchangeable:
| | CJC-1295 with DAC | CJC-1295 without DAC | | --- | --- | --- | | Also called | CJC-1295 (full) | Mod GRF 1-29 | | DAC conjugate | Yes | No | | Albumin binding | Yes — via the DAC group | No | | Half-life in models | Markedly extended | Short, typical of unconjugated GHRH analogues | | In our catalogue | The Hulk Stack | The CJC-1295 single |
DAC stands for Drug Affinity Complex — a conjugated group that binds covalently to serum albumin. Because albumin circulates for a long time, tethering the peptide to it markedly extends how long the compound persists, relative to the unconjugated version which is cleared quickly.
The practical consequence for a study design is that the two variants produce very different exposure profiles. If your protocol depends on short, pulsatile exposure, the No-DAC form is the relevant variant; if it depends on sustained receptor occupancy, the DAC form is. Reaching for the wrong one is not a minor substitution.
The Hulk Stack contains the DAC form. The CJC-1295 we sell as a single compound is the No-DAC form. See what is CJC-1295? for the single.
What each compound is
- CJC-1295 (with DAC) is a synthetic analogue of growth-hormone-releasing hormone (GHRH 1-29) with amino-acid substitutions that improve stability, plus the DAC conjugate. It binds and activates the GHRH receptor on pituitary-derived cells.
- Ipamorelin is a synthetic pentapeptide growth-hormone secretagogue, refined from GHRP-1. It is an agonist at the ghrelin / GH-secretagogue receptor (GHSR-1a) on pituitary somatotrophs. See what is Ipamorelin?
Why the two are studied together
Because they engage distinct receptors on the same cells. That is what makes the pairing informative rather than redundant — you are not stacking two compounds that do the same thing, you are running two inputs into one system.
Examining both within a single experimental setup lets researchers compare convergent versus independent signalling: whether downstream responses are additive, synergistic, or unrelated under defined exposure conditions. It also supports work on receptor cross-talk and dual-pathway regulation within the somatotropic axis.
A further point specific to Ipamorelin: published work reports that at concentrations effective for stimulating growth-hormone release in experimental models, it does not trigger adrenocorticotropic hormone (ACTH) or cortisol secretion — unlike some earlier GHRPs such as GHRP-2 and GHRP-6. That selectivity is why it is often the secretagogue of choice when the aim is to isolate GH-specific signalling from broader hypothalamic–pituitary–adrenal activity.
What the grouping does and does not claim
The set is a research convenience format. It makes no claim about a combined effect. Both compounds are supplied so that a laboratory can obtain a consistent, documented pairing rather than sourcing and matching two lots separately. Reported responses vary with concentration, exposure time and model system, and this is in-vitro and preclinical work only.
Handling and verification
The set ships with batch-specific Certificate of Analysis documentation. Refrigerate at 2–8°C on arrival, keep vials sealed and away from light, and do not freeze them. See how to store research peptides.
Browse the Hulk Stack, or the components individually as CJC-1295 (No DAC) and Ipamorelin. For the pairing studied without the DAC modification, see CJC-1295 and Ipamorelin.
Hulk Stack
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Frequently asked questions
- What is in the Hulk Stack?
- CJC-1295 with DAC and Ipamorelin, at 20mg total. CJC-1295 is a GHRH analogue acting at the GHRH receptor; Ipamorelin is a selective agonist at the ghrelin / GH-secretagogue receptor (GHSR-1a). Supplied for in-vitro laboratory research use only.
- Does the Hulk Stack use CJC-1295 with DAC or without?
- With DAC. This is a different variant from the CJC-1295 sold as a single compound on this site, which is the No-DAC form (Mod GRF 1-29). The two are not interchangeable in a study design.
- What does DAC actually do?
- DAC stands for Drug Affinity Complex — a conjugated group that binds serum albumin. Because albumin circulates for a long time, tethering the peptide to it markedly extends how long the compound persists, relative to the unconjugated form which is cleared quickly.
- Why are CJC-1295 and Ipamorelin studied together?
- They engage distinct receptors on the same pituitary cells, so the pairing is informative rather than redundant. Running both in one system lets researchers compare whether downstream responses are additive, synergistic or unrelated.
- Is the Hulk Stack the same as the CJC-1295 and Ipamorelin guide?
- That guide covers the pairing generally, based on the No-DAC CJC-1295 sold as a single. The Hulk Stack uses the DAC form, which has a substantially different exposure profile, so the two are worth reading together rather than treating as the same thing.