Melanotan II | 20mg | 3ml
Melanotan
Strength
20mg
Purity
≥99% HPLC
COA
On request
Melanotan II (MT‑II) is a synthetic cyclic heptapeptide analogue of α‑melanocyte‑stimulating hormone (α‑MSH), developed for controlled laboratory investigation of the melanocortin signalling system. Its sequence — Ac‑Nle‑cyclo[Asp‑His‑D‑Phe‑Arg‑Trp‑Lys]‑NH₂ — incorporates a norleucine substitution, a D‑phenylalanine substitution, and a lactam bridge that cyclises the molecule, conferring markedly greater stability and resistance to enzymatic degradation than the native linear hormone. These structural features make MT‑II a robust reference compound for receptor‑pharmacology and structure–activity research.\n\nIn biochemical and cellular research systems, MT‑II acts as a broad, non‑selective agonist across the melanocortin receptor family — MC1R, MC3R, MC4R and MC5R — with negligible activity at MC2R. This wide receptor coverage makes it a foundational tool for probing melanocortin‑receptor binding, G‑protein‑coupled cAMP signalling, and downstream transcriptional responses, as well as for comparative selectivity studies against more receptor‑selective analogues. The molecular responses observed vary according to receptor subtype, peptide concentration, exposure time, cell model, and overall study design, and MT‑II is employed to characterise melanocortin‑receptor signalling rather than to infer defined biological or physiological effects.
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| Designation | Cyclic α-MSH analogue (MT-II) |
| CAS Number | 121062-08-6 |
| Molecular Formula | C₅₀H₆₉N₁₅O₉ |
| Molecular Weight | 1024.2 g/mol |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ |
| Strength | 20mg |
| Presentation | 3ml Vial , Pen and Needles |
| Purity | ≥99% (HPLC) |
| Storage | Must be kept in a refrigerator at 2°C–8°C for optimal potency. |
Melanotan II
£100.00
Melanotan II — research FAQs
- What is Melanotan II?
- Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH), developed for controlled laboratory investigation of the melanocortin signalling system. Its sequence incorporates a norleucine substitution, a D-phenylalanine substitution and a lactam bridge that cyclises the molecule, conferring markedly greater resistance to enzymatic degradation than the native linear hormone. It is supplied strictly for in-vitro laboratory research use only.
- What is Melanotan II studied for in research?
- In biochemical and cellular systems MT-II acts as a broad, non-selective agonist across the melanocortin receptor family — MC1R, MC3R, MC4R and MC5R — with negligible activity at MC2R. That wide receptor coverage makes it a foundational reference tool for probing melanocortin-receptor binding, G-protein-coupled cAMP signalling and downstream transcriptional responses, and for comparative selectivity studies against more receptor-selective analogues. These are laboratory observations only and are not established effects in humans or animals.
- What is the regulatory position on Melanotan in the UK?
- The MHRA has repeatedly warned that products containing Melanotan sold for human use are unlicensed and unlawful to supply for that purpose, and has acted against suppliers marketing them for tanning or cosmetic use. Melanotan II is not a licensed medicine in the UK. Material supplied here is research-grade, sold strictly as a laboratory reference compound for in-vitro use, and must not be used in humans or animals.
- How does Melanotan II differ from PT-141?
- The two share the same cyclic scaffold. Melanotan II is C-terminally amidated (-NH₂) and acts broadly across the melanocortin receptor family; PT-141 (bremelanotide) carries a free acid (-OH) instead, which shifts it toward MC4R selectivity with markedly reduced MC1R activity. The pair is commonly used comparatively in receptor-selectivity research.
- How is Melanotan II supplied, stored and handled for research?
- Melanotan II is supplied in a sealed vial and shipped cold-chain. Refrigerate at 2°C–8°C as indicated on the label, keep the vial sealed and away from light, and check the batch Certificate of Analysis supplied with your order for the recorded appearance and presentation. Handling should follow standard aseptic laboratory practice, strictly for in-vitro research use only.