PRE ORDER MetaFrame™ (IPAMORELIN)

Concentration: 9mg

Storage: Must be kept in a refrigerator at 2°C–8°C for optimal potency.

Status: For research purposes only

Contents: Vial, needles & autoinjector pen  

THIS ITEM IS PRE ORDER ONLY - LIMITED STOCK AVAILABLE 

Description & Mechanism

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue created through structural refinement of the earlier peptide GHRP‑1. It is recognised as the first growth hormone–releasing peptide (GHRP) receptor agonist designed with high selectivity, showing a specificity for growth hormone stimulation comparable to that of endogenous growth hormone‑releasing hormone (GHRH).

In biochemical and cellular research environments, ipamorelin functions as an agonist at the ghrelin/growth hormone secretagogue receptor (GHSR‑1a), which is expressed on pituitary somatotrophs. Compared with earlier GHRPs such as GHRP‑2 and GHRP‑6, ipamorelin displays a distinct selectivity profile: experimental work has shown that, at concentrations effective for stimulating growth hormone release, it does not trigger adrenocorticotropic hormone (ACTH) or cortisol secretion. This characteristic makes ipamorelin a useful research compound for isolating growth hormone–specific signalling pathways without concurrent activation of the hypothalamic–pituitary–adrenal (HPA) axis. In controlled animal studies, ipamorelin has also been associated with dose‑dependent increases in longitudinal bone growth.

Applications in Research

• Analysis of GHSR‑1a receptor binding characteristics, selectivity, and downstream signalling
• Examination of growth hormone secretagogue activity independent of HPA axis involvement
• Research into pituitary somatotroph physiology and growth hormone release dynamics
• Comparative in vitro and in vivo studies alongside other GHRPs (GHRP‑2, GHRP‑6, Hexarelin)
• Experimental models exploring GH/IGF‑1 axis regulation and bone‑growth‑related signalling
• Use as a selective reference peptide in neuroendocrine and peptide‑signalling investigations

Free express shipping on all orders.