What is KPV?
4 min read · Updated May 2026
KPV is a synthetic tripeptide of lysine-proline-valine, corresponding to residues 11-13 of α-melanocyte-stimulating hormone (α-MSH). It is widely used in research as the smallest functional fragment of α-MSH capable of engaging melanocortin-associated signalling without the full-length hormone.
Research use only. KPV is supplied strictly for in-vitro laboratory research. This page does not describe dosing, administration, or use in humans or animals, and makes no therapeutic claims.
What researchers study
In biochemical and cellular systems, KPV is examined for its influence on melanocortin-linked signalling networks and downstream processes involved in immune activity and inflammatory regulation. Research typically focuses on both receptor-associated and receptor-independent mechanisms, transcriptional responses and peptide stability, with effects varying by concentration, model and design.
Typical research applications include:
- Analysing melanocortin-related signalling mechanisms
- Studying peptide-mediated modulation of inflammatory and immune-related pathways
- In-vitro work on short-peptide signalling behaviour and stability
How it is supplied
KPV is supplied as a lyophilised vial with a Certificate of Analysis, stored refrigerated at 2–8°C. It is also a component of the Klow Stack.