What is GHK-Cu?
5 min read · Updated May 2026
GHK-Cu is an endogenous copper-peptide complex — the tripeptide glycyl-L-histidyl-L-lysine bound to a divalent copper ion (Cu²⁺) in a high-affinity chelated structure. In research it is valued because it lets investigators study signalling driven by both the peptide component and the biochemistry of copper itself.
Research use only. GHK-Cu is supplied strictly for in-vitro laboratory research. This page does not describe dosing, administration, or use in humans or animals, and makes no therapeutic claims.
What researchers study
Copper is an essential trace element for many enzymes and structural proteins involved in redox balance, extracellular-matrix formation and metabolism. By acting as a carrier and regulator of bioavailable copper, GHK-Cu is studied as a tool for copper-dependent signalling and peptide–metal interactions. Across preclinical systems it has been linked to shifts in gene expression and modulation of pathways governing matrix turnover, oxidative-stress responses and cellular renewal — with outcomes varying by concentration, exposure and model.
Typical research applications include:
- Examining copper transport, binding behaviour and metal homeostasis
- Exploring copper-dependent signalling in cell growth and differentiation
- Cell-based assays of gene expression, redox signalling and matrix regulation
How it is supplied
GHK-Cu is supplied as a lyophilised vial with a Certificate of Analysis, stored refrigerated at 2–8°C. It is also a component of the Glow Stack and Klow Stack.