What is TB-500?
5 min read · Updated May 2026
TB-500 is a synthetic peptide based on the active region of thymosin beta-4, used in controlled experiments focused on actin-binding behaviour, cellular migration and cytoskeletal organisation. It serves as a research analogue for examining how thymosin-beta-4-related sequences influence structural and motility-associated cellular processes.
Research use only. TB-500 is supplied strictly for in-vitro laboratory research. This page does not describe dosing, administration, or use in humans or animals, and makes no therapeutic claims.
What researchers study
In biochemical and cell-based systems, thymosin-beta-4-derived peptides are evaluated for their ability to interact with G-actin, affecting actin polymerisation and broader cytoskeletal remodelling. Responses observed in experimental models vary with peptide concentration, exposure time, cell type and study design.
Typical research applications include:
- Investigating actin dynamics and cytoskeletal regulation
- In-vitro studies of cell migration and structural organisation
- Models assessing tissue architecture and repair-related signalling pathways
How it is supplied
TB-500 is supplied as a lyophilised vial with a Certificate of Analysis, stored refrigerated at 2–8°C. It is also a component of the Wolverine Stack and Glow Stack research compound sets.