What is MOTS-c?
5 min read · Updated May 2026
MOTS-c is a synthetic version of a naturally occurring mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. In research it is used to explore mitochondrial signalling, metabolic regulation, and communication between the mitochondria and the nucleus.
Research use only. MOTS-c is supplied strictly for in-vitro laboratory research. This page does not describe dosing, administration, or use in humans or animals, and makes no therapeutic claims.
What researchers study
In biochemical and cellular models, MOTS-c has been shown to influence pathways tied to energy sensing, insulin-related signalling and cellular stress adaptation. Experimental systems often assess its impact on AMPK activation, metabolic gene regulation and stress-responsive signalling cascades, with effects varying by concentration, exposure time and model.
Typical research applications include:
- Examining signalling driven by mitochondrial-derived peptides
- Investigating metabolic regulation and cellular energy balance
- Studying mitochondrial–nuclear communication and coordinated gene regulation
A note on NAD+
Because both sit in metabolic-research workflows, MOTS-c is often studied in the same context as NAD+ — see what is NAD+?.
How it is supplied
MOTS-c is supplied as a lyophilised vial with a Certificate of Analysis, stored refrigerated at 2–8°C.